In modern day a young newlywed couple, taking a haunted honeymoon tour around the country, comes to Briarcliff, an old insane asylum that reached its peak of weird in the sixties, its most famous patient a violent serial killer called Bloody Face. Not too long after arriving the couple is killed by an unseen force and we are flash-backed to the sixties where we see Briarcliff in its day. Not too different than its current proceedings it is a grimy patient care facility that is supervised by the cruel Sister Jude and run by Rome driven Monsignor Timothy Howard. Of its newly recent patients there's Kit Walker, a twenty some year old average Joe who's wife was brutally murdered by the unknown killer Bloody Face. Mistaken for her murderer Kit is thrown into Briarcliff and is committed as he claims aliens abducted him then killed his wife Alma. With his face now being the poster child of the violent crimes where the killer has been skinning the women he captures and wearing their skin as a mask Kit's arrest attracts Lana Winters to Briarcliff. A journalist Lana has all the right girth as a reporter who'll do anything to get her story but her nosing in Briarcliff and its conditions lands her a bed in the hospital, her condition symptom by Sister Jude of her interest in the same sex. Inside Briarcliff Kit and Lana are exposed to the often inhumane treatments and unsanitary living conditions the hospital offers. Not to mention its sometimes mid-evil practices for punishment. The only option the two have is to prove their innocence as the real Bloody Face killer is still lurking around. But along the way they have other horrors to triumph over which include Sister Mary Eunice who's purity is left dead inside her by a malevolent demon and Briarcliff's own residing doctor, Doctor Arden, who's experiments and history bring a whole new shade of evil to the patients.